Nicole DeHuff was born on 6 January 1975 in Oklahoma. She began her acting studies at the prestigious Carnegie Mellon Acting Conservatory. Her first screen role was in the comedy hit Ti presento i miei (2000), in which she co-starred with Robert De Niro and Ben Stiller. Her character (Deborah Byrnes) was the sister whose wedding caused chaos for her family. She subsequently appeared in a guest capacity in such television programs as CSI: Miami (2002), Detective Monk (2002) and The Practice - Professione avvocati (1997). Nicole married in 2000 to Ari Palitz, but had no children. She passed away from pneumonia on 16 February 2005 in Los Angeles. She was 30 years old.
